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KMID : 1134220070270030034
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Hanyang Medical Reviews
2007 Volume.27 No. 3 p.34 ~ p.40
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athogenesis of Helicobacter pylori-induced Gastric Cell Injury
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Park Sang-Woon
Hahm Ki-Baik
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Abstract
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H. pylori infection has been revealed to cause chronic gastric inflammation, which may progress to gastric ulcers and duodenal ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphoma as well as gastric adenocarcinoma.
The mechanisms by which bacterial infection leads to gastric mucosal damage include the direct effects of virulence factors produced by H. pylori, such as cagA, vacA or urease, the propagation and perpetuation of inflammation, oxidative
stress, and the induction of apoptosis in infected gastric epithelial cells. In the current review, the pathogenic mechanisms with their clinical relevance will be described.
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KEYWORD
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Helicobacter pylori, Gastric Cell Injury, Pathogenesis
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